Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors
The combination of multiomics analysis and drug sensitivity profiling identified two signatures related to drug sensitivity in pediatric solid tumors, contributing to the advancement of functional precision medicine and personalized treatment strategies. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI .
Authors
- Ina Oehme (ORCID: https://orcid.org/0000-0002-0827-2356)
- Sina Oppermann (ORCID: https://orcid.org/0000-0002-9101-260X)
- Julio Sáez-Rodríguez (ORCID: https://orcid.org/0000-0002-8552-8976)
- Heike Peterziel (ORCID: https://orcid.org/0000-0001-9261-7144)
- Rosa Hernansaiz-Ballesteros (ORCID: https://orcid.org/0000-0001-8536-8848)
- Gnana Prakash Balasubramanian (ORCID: https://orcid.org/0000-0003-3901-1244)
- Rolf Kabbe (ORCID: https://orcid.org/0009-0003-7800-9769)
- Stefan M. Pfister (ORCID: https://orcid.org/0000-0002-5447-5322)
- Dina ElHarouni (ORCID: https://orcid.org/0000-0003-1488-0347)
- Christopher Previti (ORCID: https://orcid.org/0009-0008-5452-0075)
- Matthias Schlesner (ORCID: https://orcid.org/0000-0002-5896-4086)
- Mirjam Blattner-Johnson (ORCID: https://orcid.org/0009-0000-2054-9998)
- David Jones (ORCID: https://orcid.org/0000-0002-2036-5141)
- Olaf Witt (ORCID: https://orcid.org/0000-0003-3918-9157)
- Barbara C. Jones (ORCID: https://orcid.org/0009-0003-9087-6013)
- Natalie Jäger (ORCID: https://orcid.org/0000-0002-9589-7580)
- Kathrin Schramm (ORCID: https://orcid.org/0009-0006-7355-6378)
Institutions
- Goethe University Frankfurt (DE)
- University of Augsburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- National Center for Tumor Diseases (DE)
- Hopp Children's Cancer Center Heidelberg (DE)
- DKFZ-ZMBH Alliance (DE)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1158/0008-5472.can-24-1938
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto
- Deutsches Krebsforschungszentrum
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Gesundheit
- Deutsche Krebshilfe
- Deutschen Konsortium für Translationale Krebsforschung
- Biocenter Finland