Connectivity between the seizure onset zone and the thalamus correlates with seizure outcomes in thalamic responsive neurostimulation
Greater recruitment of white matter connections between the SOZ and thalamus is associated with clinical response and may correlate with improved seizure outcomes during thalamic RNS. Using tractography to map the patient-specific "thalamic seizure network" and the surgical targeting of these connections may result in improved clinical outcomes in patients treated with thalamic RNS.
Authors
- Hesham T. Ghonim (ORCID: https://orcid.org/0000-0001-9625-642X)
- Madeline Fields (ORCID: https://orcid.org/0000-0003-0661-4153)
- Maite La Vega‐Talbott
- Yunju Im (ORCID: https://orcid.org/0000-0001-7596-3803)
- Josué M. Avecillas-Chasín (ORCID: https://orcid.org/0000-0001-5627-9643)
- Lakshman Arcot Jayagopal (ORCID: https://orcid.org/0000-0003-1259-0610)
- Juan A. Barcia (ORCID: https://orcid.org/0000-0001-6562-4568)
- Daniel D. Cummins (ORCID: https://orcid.org/0000-0003-2742-5669)
- Varun R. Subramaniam (ORCID: https://orcid.org/0000-0002-3005-8006)
- Saadi Ghatan (ORCID: https://orcid.org/0000-0002-9710-7693)
- Andy Ho Wing Chan (ORCID: https://orcid.org/0009-0002-5055-9470)
- Fedor Panov (ORCID: https://orcid.org/0009-0009-7117-4036)
- Lara Marcuse (ORCID: https://orcid.org/0000-0002-1494-7241)
Institutions
- Nebraska Medical Center (US)
- Hospital Clínico San Carlos (ES)
- University of Nebraska Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1002/epi.70052
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00