An Unusual Presentation of Acquired Perforating Dermatosis Confined to the Scalp

Acquired perforating dermatosis (APD) is a rare skin disorder characterized by transepidermal elimination of dermal connective tissue components. We report the case of a 31-year-old man with end-stage renal disease on hemodialysis and type 1 diabetes mellitus who presented with APD lesions confined to the scalp, an uncommon site for this condition. Histopathological examination confirmed the diagnosis, revealing transepidermal elimination of degenerated collagen bundles. Sequential treatment with oral clindamycin followed by allopurinol resulted in marked clinical improvement and complete resolution within one month of therapy.

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Publication Details

Journal
Cureus
Published
2025-12-19
DOI
https://doi.org/10.7759/cureus.99636
Primary Topic
Dermatological and Skeletal Disorders
Type
article
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0.00
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article

An Unusual Presentation of Acquired Perforating Dermatosis Confined to the Scalp

M. Lambertini, A. Giuliani, A. Lambertini, Valeria Taboada et al.
Cureus
Dermatological and Skeletal Disorders
article

An Unusual Presentation of Acquired Perforating Dermatosis Confined to the Scalp

M. Lambertini, A. Giuliani, A. Lambertini, Valeria Taboada, Gabriela Montecchiesi
article en

Abstract

Acquired perforating dermatosis (APD) is a rare skin disorder characterized by transepidermal elimination of dermal connective tissue components. We report the case of a 31-year-old man with end-stage renal disease on hemodialysis and type 1 diabetes mellitus who presented with APD lesions confined to the scalp, an uncommon site for this condition. Histopathological examination confirmed the diagnosis, revealing transepidermal elimination of degenerated collagen bundles. Sequential treatment with oral clindamycin followed by allopurinol resulted in marked clinical improvement and complete resolution within one month of therapy.

CureusVol. 17(12)
Austral University (AR), General de Jesus College (PH)
Openalex Percentile: Top 57%
Dermatological and Skeletal Disorders
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