Clinical predictors of TRAb decline after total thyroidectomy in patients with Graves’ disease
In this large post-operative cohort, younger age emerged as an independent predictor of accelerated TRAb decline after total thyroidectomy. Total thyroidectomy yields sustained TRAb decline and may promote immunological remission, particularly in younger patients, by removing the antigenic source before the establishment of long-lived plasma cells. These findings highlight age as a key determinant of TRAb kinetics and provide timelines for counselling and follow-up. Surgery may be especially valuable when a timely TRAb decline is required, such as in younger patients planning pregnancy or those with orbitopathy or antithyroid drug refractoriness.
Authors
- Akira Miyauchi (ORCID: https://orcid.org/0000-0003-0041-197X)
- Akihiro Miya (ORCID: https://orcid.org/0000-0003-1891-7135)
- Minoru Kihara (ORCID: https://orcid.org/0000-0003-1778-5177)
- Hiroo Masuoka (ORCID: https://orcid.org/0000-0001-9850-4159)
- Takahiro Sasaki (ORCID: https://orcid.org/0000-0001-9513-5036)
- Takashi Akamizu (ORCID: https://orcid.org/0000-0003-4960-8271)
- Naoyoshi Onoda (ORCID: https://orcid.org/0000-0002-4361-1827)
- Yasuhiro Ito (ORCID: https://orcid.org/0000-0002-2069-4658)
- Makoto Fujishima (ORCID: https://orcid.org/0009-0006-4537-9423)
- Takuya Higashiyama
Institutions
- Kuma Hospital (JP)
- Kobe University (JP)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1530/etj-25-0284
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00