Tumor-informed liquid biopsy for monitoring thyroid cancer: a proof-of-concept study
This cross-sectional analysis demonstrated that liquid biopsy accurately reflected disease activity and showed strong concordance with primary tumor alterations. These findings support its feasibility and clinical potential as an adjunct to conventional monitoring, particularly when Tg measurement or tumor tissue availability is limited. Prospective longitudinal studies are warranted to validate its role in personalized postoperative surveillance of thyroid cancer.
Authors
- Fabiano Callegari (ORCID: https://orcid.org/0000-0002-5547-599X)
- Aline de Oliveira Ribeiro Viana (ORCID: https://orcid.org/0009-0000-4678-1592)
- Renata Elen Costa da Silva
- Rosa Paula M. Biscolla (ORCID: https://orcid.org/0000-0003-4358-6622)
- José de Lima Albuquerque (ORCID: https://orcid.org/0000-0003-0625-5656)
- Julia Maranhão Fagundes Velloni (ORCID: https://orcid.org/0000-0002-8698-6995)
- João Roberto Maciel Martins (ORCID: https://orcid.org/0000-0002-0204-3552)
- Otávio Alberto Curioni (ORCID: https://orcid.org/0000-0002-2674-4441)
- Débora Mota Dias Thomaz
- Janete M. Cerutti (ORCID: https://orcid.org/0000-0003-0156-8274)
- Welbert Gomes Rocha (ORCID: https://orcid.org/0000-0002-7395-3342)
Institutions
- Hospital Heliópolis (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1530/etj-25-0255
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00