Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis
The humanised KC-Cpa1 mouse model reveals the interplay of inflammation in hereditary CP and carcinogenesis. <i>Cpa1<sup>N256K</sup></i> -induced plasticity in acinar and ductal cells, inflammation and cell-cell interaction networks cooperate with <i>Kras<sup>G12D</sup></i> in early pancreatic carcinogenesis.
Authors
- Helmut Laumen (ORCID: https://orcid.org/0000-0002-5885-5242)
- Markus Glaß (ORCID: https://orcid.org/0000-0003-2718-8907)
- Patrick Michl (ORCID: https://orcid.org/0000-0002-0401-5600)
- Ivonne Regel (ORCID: https://orcid.org/0000-0002-0206-4441)
- Michael Boettcher (ORCID: https://orcid.org/0000-0003-0986-4465)
- Heidi Griesmann (ORCID: https://orcid.org/0000-0003-0701-2947)
- Nico Hesselbarth
- Atul Verma (ORCID: https://orcid.org/0000-0002-1020-9727)
- Tom Kaune (ORCID: https://orcid.org/0000-0002-7684-4598)
- Jonas Rosendahl (ORCID: https://orcid.org/0000-0003-4513-0506)
- Mariami Jasaszwili (ORCID: https://orcid.org/0000-0002-2821-5076)
- Iréne Esposito (ORCID: https://orcid.org/0000-0002-0554-2402)
- Tanvi Vikrant Inamdar
- Teresa Vauti
- Ghanem El Kassem (ORCID: https://orcid.org/0009-0009-2623-0684)
- Jasmine Hillmer
- Monika Hämmerle
- Ferdinand Krannich
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Düsseldorf University Hospital (DE)
- Heinrich Heine University Düsseldorf (DE)
- Martin Luther University Halle-Wittenberg (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Gut
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1136/gutjnl-2025-335947
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Deutsche Forschungsgemeinschaft