The interplay between PROM score distributions and treatment effect detection likelihood in randomized controlled trials–a metaepidemiologic study
The concentration of PROM score distributions toward the high end of the scale, especially when higher baseline scores are present, diminishes the likelihood of detecting significant differences between study groups, particularly at follow-up assessments in studies analyzing musculoskeletal complaints. This underscores the importance of critically evaluating the conclusions drawn from these studies.
Authors
- Juho Laaksonen (ORCID: https://orcid.org/0000-0002-9328-4721)
- Matias Vaajala (ORCID: https://orcid.org/0000-0002-1294-6173)
- Mikko Uimonen (ORCID: https://orcid.org/0000-0001-6609-1345)
- Valtteri J. Panula (ORCID: https://orcid.org/0000-0001-6638-3188)
- Ville Ponkilainen (ORCID: https://orcid.org/0000-0002-5026-4560)
- Antti Saarinen (ORCID: https://orcid.org/0000-0002-2742-8491)
- Rasmus Liukkonen (ORCID: https://orcid.org/0000-0002-2514-3193)
- Oskari Pakarinen (ORCID: https://orcid.org/0000-0002-0159-5830)
- Ilari Kuitunen (ORCID: https://orcid.org/0000-0001-8178-9610)
Institutions
- University of Turku (FI)
- Tampere University (FI)
- University of Eastern Finland (FI)
- Turku University Hospital (FI)
- Kuopio University Hospital (FI)
- Tampere University Hospital (FI)
- Päijät-Hämeen Keskussairaala (FI)
- Tampere University (FI)
Publication Details
- Journal
- Journal of Clinical Epidemiology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.jclinepi.2025.112114
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00