LncRNA H19 Upregulation Links Hypoplastic Left Heart Syndrome to Impaired PINK1/Parkin-Mediated Mitophagy and Ischemic Vulnerability
H19 upregulation impairs PINK1/Parkin-dependent mitophagy and increases susceptibility to ischemic and hypoxic injury in HLHS and the immature heart. These findings identify H19 as a key regulator of mitochondrial quality control and a potential therapeutic target for mitigating IRI in early-life cardiac disease.
Authors
- David S. Winlaw (ORCID: https://orcid.org/0000-0001-8005-3361)
- Connor Lantz (ORCID: https://orcid.org/0000-0003-3317-6486)
- Pedro Lara
- Edward B. Thorp (ORCID: https://orcid.org/0000-0003-1387-7058)
- Zhi‐Dong Ge (ORCID: https://orcid.org/0000-0002-7045-0846)
- My Linh Thi Nguyen
- Michael C. Mongé (ORCID: https://orcid.org/0000-0002-7911-5382)
- Gregory B. Waypa (ORCID: https://orcid.org/0000-0002-6179-4209)
- Kristofor Glinton (ORCID: https://orcid.org/0000-0001-9301-7132)
- Xuebin Fu (ORCID: https://orcid.org/0000-0002-1281-2466)
- Swetha Thirukannamangai Krishnan
- Paul T. Schumacker (ORCID: https://orcid.org/0000-0001-9591-2034)
- Conrad L. Epting (ORCID: https://orcid.org/0000-0003-4400-0419)
- V. Joseph Dudley
- Ming Zhao (ORCID: https://orcid.org/0000-0001-7956-2409)
- A.S.K. Sinha (ORCID: https://orcid.org/0000-0001-6661-1013)
- Tarek Kishawi
Institutions
- Northwestern University (US)
- Medical College of Wisconsin (US)
- Lurie Children's Hospital (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-19
- DOI
- https://doi.org/10.64898/2025.12.16.694773
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Institutes of Health