Comparative molecular surveillance of polymorphisms in chloroquine resistance transporter, multidrug resistance 1, and Kelch 13 genes associated with antimalarial drug resistance in Plasmodium falciparum isolates from Western Kenya
Our findings reveal the persistence of the Pfcrt CVIET haplotype and elevated Pfk13 A675V mutation in Kisii, with a moderate prevalence of Pfmdr1 Y184F mutation in both regions. Crucially, we detected emerging novel Pfmdr1 N146I and rare Pfk13 S522C and R561H mutations in Kisumu. Given that artemether-lumefantrine is Kenya's first-line treatment, continuous molecular surveillance is essential to elucidate the selection pressures driving the spread of resistant P. falciparum in western Kenya.
Authors
- Josephat Bungei (ORCID: https://orcid.org/0000-0002-4911-8224)
- Ming‐Chieh Lee (ORCID: https://orcid.org/0000-0002-2462-6089)
- Collins Ouma (ORCID: https://orcid.org/0000-0001-8205-8887)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-1232-3125)
- Guiyun Yan (ORCID: https://orcid.org/0000-0001-8760-2925)
- Job Oyweri (ORCID: https://orcid.org/0000-0001-9784-1698)
- Daibin Zhong (ORCID: https://orcid.org/0000-0002-2771-9598)
- Harrysone Atieli (ORCID: https://orcid.org/0000-0003-0562-0674)
- John I. Githure
- Guofa Zhou
Institutions
- Maseno University (KE)
- University of California, Irvine (US)
- Centers for Disease Control and Prevention (KE)
- Monterey Bay Aquarium Foundation (US)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s12936-025-05755-2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health