Machine Learning Reveals Common Regulatory Mechanisms Mediated by Autophagy-Related Genes in the Development of Inflammatory Bowel Disease and Major Depressive Disorder
Our findings illuminate autophagy-mediated mechanisms linking gut and brain disorders. The identification of <i>CASP1</i> as a SSAG, along with candidate therapeutics, provides a foundation for future research and targeted treatments for IBD and MDD comorbidity.
Authors
- Mengmeng Sang (ORCID: https://orcid.org/0000-0001-5249-002X)
- Liucheng Wu (ORCID: https://orcid.org/0000-0002-8053-1340)
- Guishuan Wang
- Liming Mao (ORCID: https://orcid.org/0000-0002-9740-820X)
- Jiyuan Shi
Institutions
- Handan College (CN)
- Nantong University (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3390/genes17010004
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China