Imaging Hypoxia in the Diabetic Retina: A Potential Early-Detection Imaging Biomarker Before Detectable Retinopathy in Diabetes
Hyperglycemia causes retinal hypoxia. Hypoxia may lead to apoptosis of retinal cells. Retinal hypoxia can be detected before any detectable changes in the diabetic retina. HYPOX-4 is a powerful early diagnostic imaging method to detect hypoxia in the diabetic retinas of living patients.
Authors
- Md. Imam Uddin (ORCID: https://orcid.org/0000-0001-5611-9666)
- B Dieckmann (ORCID: https://orcid.org/0009-0001-0880-0323)
- D. Burgos
Institutions
- Vanderbilt University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-12-19
- DOI
- https://doi.org/10.2337/db25-0394
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Diabetes Association
- International Retinal Research Foundation
- Research to Prevent Blindness
- Vanderbilt University
- University of Pennsylvania
- National Institutes of Health
- School of Medicine, Vanderbilt University
- Vanderbilt Vision Research Center, Vanderbilt University