OPN Promotes Hepatocellular Carcinoma Progression Through the p65/c-Myc/CD155 Axis by Suppressing CD8+ T Cell Infiltration and Activation
OPN drives HCC progression by suppressing CD8<sup>+</sup> T-cell immunity through the NF-κB (p65)/c-Myc/CD155 axis. Targeting this pathway may enhance anti-tumor immunity and represents a promising therapeutic strategy for HCC.
Authors
- Jiajun Liang (ORCID: https://orcid.org/0000-0002-1100-4731)
- Jincun Fang
- Morris Ling (ORCID: https://orcid.org/0000-0002-9657-8960)
- Zhiying He (ORCID: https://orcid.org/0000-0002-0087-2277)
- Liwei Liu (ORCID: https://orcid.org/0009-0009-7935-7590)
- Yingying Lei
- Zhenzhen Wen (ORCID: https://orcid.org/0009-0000-9604-3520)
- Jingfeng Guo
Institutions
- Panyu Hospital of Chinese Medicine (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1080/08820139.2025.2599834
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00