Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway
Cardiomyocyte-derived hypoxia/reoxygenation-EVs deliver miR-199b-3p to restrain Fgl2-dependent inflammatory signaling and post-infarction injury, highlighting the EV/miR-199b-3p/Fgl2 axis as a potential therapeutic target for improving outcomes after MI.
Authors
- Zhibin Zhang
- Hechen Shen (ORCID: https://orcid.org/0000-0003-4222-6908)
- Jianghui Zhou (ORCID: https://orcid.org/0000-0002-4768-5575)
- Yun C. Chang (ORCID: https://orcid.org/0000-0002-8706-3615)
- Xiaoyu Liang (ORCID: https://orcid.org/0000-0001-7796-2441)
- Yue Zheng (ORCID: https://orcid.org/0000-0002-6281-5163)
- Yuchao Wang (ORCID: https://orcid.org/0000-0002-0927-3844)
- Meng Zhang (ORCID: https://orcid.org/0000-0002-4247-5907)
- Shijie Zhang (ORCID: https://orcid.org/0000-0002-1840-6258)
- Xiaomin Hu (ORCID: https://orcid.org/0000-0002-5921-1051)
- Wenqing Gao (ORCID: https://orcid.org/0000-0002-4085-2932)
Institutions
- Tianjin Third Central Hospital (CN)
- Tianjin Central Hospital of Gynecology Obstetrics (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.intimp.2025.116077
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00