Simulated patient systems powered by large language model-based AI agents offer potential for transforming medical education
Large language model-based simulated patient systems provide accurate, readable, and reliable medical encounters and demonstrates potential to transform medical education.
Authors
- Huizi Yu (ORCID: https://orcid.org/0000-0003-3776-9211)
- Jiayan Zhou (ORCID: https://orcid.org/0000-0001-5974-087X)
- Themistocles L. Assimes (ORCID: https://orcid.org/0000-0003-2349-0009)
- Lingyao Li (ORCID: https://orcid.org/0000-0001-5888-8311)
- Zahra Azizi (ORCID: https://orcid.org/0000-0002-7897-0934)
- Jack Gallifant (ORCID: https://orcid.org/0000-0003-1306-2334)
- Danielle S. Bitterman (ORCID: https://orcid.org/0000-0003-0345-2232)
- Jie Sun (ORCID: https://orcid.org/0000-0002-4918-9217)
- Wenyue Hua (ORCID: https://orcid.org/0009-0008-2043-2704)
- Qi Dou (ORCID: https://orcid.org/0000-0003-3083-7568)
- Jingxian He
- Xin Ma (ORCID: https://orcid.org/0000-0003-4402-1957)
- Bryan P. Yan (ORCID: https://orcid.org/0000-0003-0430-5752)
- Lizhou Fan (ORCID: https://orcid.org/0000-0002-7962-9113)
- Lin Lü (ORCID: https://orcid.org/0000-0003-0742-9072)
- Mingyu Jin (ORCID: https://orcid.org/0009-0007-6990-7355)
- Shan Chen (ORCID: https://orcid.org/0000-0001-7999-7410)
- Trisha Gupte (ORCID: https://orcid.org/0000-0003-3695-3244)
- Yongfeng Zhang (ORCID: https://orcid.org/0000-0003-2633-8555)
- Xiang Li (ORCID: https://orcid.org/0000-0002-9059-4759)
- Ming‐Li Chen (ORCID: https://orcid.org/0000-0003-0276-2626)
- Zhao Li (ORCID: https://orcid.org/0009-0009-3093-6858)
- Yang Zhou (ORCID: https://orcid.org/0000-0001-7882-9028)
- Guang Chen
- Yanqiu Xing
- Anye Shi
Institutions
- Rutgers, The State University of New Jersey (US)
- Broad Institute (US)
- Harvard University (US)
- University of Ottawa (CA)
- Shandong University (CN)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Cornell University (US)
- University of Michigan (US)
- Peking Union Medical College Hospital (CN)
- Peking University Third Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Peking University Sixth Hospital (CN)
- Artificial Intelligence in Medicine (Canada) (CA)
- University of Hong Kong (HK)
- Stanford University (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1038/s43856-025-01283-x
- Citations
- 5
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Institutes of Health