Impact of surface functional group modification on cellular internalization and cytotoxicity of silica nanoparticles
NH<sub>2</sub>- or COOH-functionalization reduced the harmful changes observed with OH- SiO<sub>2</sub>NPs, which included increase in lung weight and BALF neutrophils at low dose in mice as well as decrease in cell viability and upregulation of proinflammatory cytokines in RAW264.7 macrophages. The results suggested that OH-SiO<sub>2</sub>NPs-induced cytotoxicity against macrophages was mediated at least in part through apoptotic/necroptotic signaling but was not related to internalization of particles. The results imply possible development of safer silica nanoparticles by amino- or carboxyl-functionalization of their silanols.
Authors
- Yurika Osada
- Akira Sato (ORCID: https://orcid.org/0000-0002-2239-6208)
- Kyoka Yamazaki
- Lang Tran
- Ryo Abe (ORCID: https://orcid.org/0000-0003-2603-6784)
- Yasushi Hara (ORCID: https://orcid.org/0000-0002-0528-3252)
- Toshihiro Sakurai (ORCID: https://orcid.org/0000-0003-1759-3802)
- Takatsugu Wakahara (ORCID: https://orcid.org/0000-0002-6365-3215)
- Akihiko Ikegami (ORCID: https://orcid.org/0000-0002-9869-5001)
- Gaku Ichihara (ORCID: https://orcid.org/0000-0001-5707-5300)
- Yuya Terashima (ORCID: https://orcid.org/0000-0003-3127-367X)
- Sonja Boland (ORCID: https://orcid.org/0000-0002-4257-4104)
- Sahoko Ichihara (ORCID: https://orcid.org/0000-0002-7224-0949)
- Cai Zong (ORCID: https://orcid.org/0000-0002-4748-081X)
- Wenting Wu (ORCID: https://orcid.org/0000-0002-8380-7904)
- Sakie Takeuchi
- Sandra Vranic (ORCID: https://orcid.org/0000-0002-6653-7156)
- Kayoko Miyakawa
- Toshihiro Suzuki (ORCID: https://orcid.org/0000-0002-7803-3801)
- Eri Watanabe (ORCID: https://orcid.org/0000-0003-4907-3713)
- Kouji Matsushima
Institutions
- Centre National de la Recherche Scientifique (FR)
- Jichi Medical University (JP)
- Tokyo University of Science (JP)
- Université Paris Cité (FR)
- National Institute for Materials Science (JP)
- Wellcome Centre for Cell-Matrix Research (GB)
- Institute of Occupational Medicine (GB)
- Department of Health (IE)
- Unit of Functional and Adaptive Biology (FR)
- Nagoya University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s12989-025-00653-6
- Citations
- 1
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.52