Interferon therapy-induced reduction in PD-1 + CD8 + and CD160 + CD8 + T cells is associated with functional cure in hepatitis B
Peg-IFN-α may promote HBsAg clearance in selected HBeAg-negative patients with low antigen burden and partially reversible T-cell exhaustion.
Authors
- Jiangyu Liu
- Ling Qin (ORCID: https://orcid.org/0000-0001-8717-3833)
- Daqiong Zhou (ORCID: https://orcid.org/0009-0008-4266-8152)
- Jianru Jia
- Hong Li (ORCID: https://orcid.org/0000-0002-2714-2135)
- Zichen Zhang (ORCID: https://orcid.org/0000-0001-8376-0539)
- Zhenhuan Cao (ORCID: https://orcid.org/0000-0002-6522-0093)
Institutions
- Capital Medical University (CN)
- Beijing YouAn Hospital (CN)
- Baoding People's Hospital (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s12879-025-12042-7
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00