IL-21 attenuates liver inflammation by enhancing myeloid-derived suppressor cells immunosuppressive function in chronic HBV infection
These results reveal that IL-21 enhances MDSC-mediated immunosuppression, implicating this regulatory axis in the attenuation of hepatic inflammation during chronic HBV infection. These findings provide a novel perspective on the involvement of IL-21 in the negative regulation of intrahepatic inflammation and provide a novel perspective on the role of IL-21 in developing immunotherapeutic strategies to optimize available anti-inflammatory treatments in chronic HBV infection.
Authors
- Zheyu Dong (ORCID: https://orcid.org/0000-0001-6527-3868)
- Geetha Rao (ORCID: https://orcid.org/0009-0007-2744-9309)
- Guofu Ye
- Weiying He (ORCID: https://orcid.org/0000-0003-0241-7056)
- Zihan Jin
- Libo Tang (ORCID: https://orcid.org/0000-0002-7905-5893)
- Yongyin Li (ORCID: https://orcid.org/0000-0001-6303-7642)
- Min‐Hsiung Pan (ORCID: https://orcid.org/0000-0002-5188-7030)
- Xiaoyi Li (ORCID: https://orcid.org/0000-0002-3725-259X)
- Zhipeng Liu (ORCID: https://orcid.org/0000-0001-7159-5038)
- Hongjie Chen (ORCID: https://orcid.org/0000-0003-3139-5706)
- Junlin Chen (ORCID: https://orcid.org/0000-0002-0328-6898)
- Shihong Zhong
Institutions
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s12967-025-07406-1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Southern Medical University
- Nanfang Hospital
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province