Reference-guided computational framework identifies microenvironment metabolic subtypes and targets using pan-cancer single-cell datasets
MetroSCREEN is a robust and scalable approach for characterizing metabolic heterogeneity and pinpointing metabolic regulators at single-cell resolution, unveiling novel antitumor targets for future metabolic interventions. The source codes of MetroSCREEN is available at the Github site https://github.com/wanglabtongji/MetroSCREEN .
Authors
- Xin Dong (ORCID: https://orcid.org/0000-0002-7112-0224)
- Qiu Wu (ORCID: https://orcid.org/0000-0003-4796-4520)
- Taiwen Li (ORCID: https://orcid.org/0000-0001-7940-8196)
- Ya Han (ORCID: https://orcid.org/0000-0003-1892-4239)
- Tong Han (ORCID: https://orcid.org/0000-0003-0802-9281)
- Chenfei Wang (ORCID: https://orcid.org/0000-0001-7573-3768)
- Hailin Wei
- Ke Tang (ORCID: https://orcid.org/0000-0002-0516-4667)
- Dongqing Sun (ORCID: https://orcid.org/0009-0007-7302-1880)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-7115-1389)
- Zhaoyang Liu (ORCID: https://orcid.org/0000-0002-3992-701X)
- Lele Zhang (ORCID: https://orcid.org/0000-0002-5595-3103)
- Wenwen Shao (ORCID: https://orcid.org/0009-0002-8888-3225)
- Junjie Hu (ORCID: https://orcid.org/0009-0001-2389-3011)
Institutions
- Tongji University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Shanghai FRP Research Institute (China) (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s13073-025-01572-z
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Tongji University