Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by <i>Pseudomonas aeruginosa</i> Pyocyanin in Human Nasal Epithelial Cells
Ca<sup>2+</sup> signaling is not required for phenazine mitochondrial toxicity. The greater sensitivity of cancer cells to phenazine cytotoxicity necessitates use of primary cells when studying host responses to bacterial phenazines. Enhanced ROS production and ciliotoxicity in CF-CRS may contribute to susceptibility to P. aeruginosa infection.
Authors
- Zoey A. Miller (ORCID: https://orcid.org/0000-0002-1955-4033)
- James N. Palmer (ORCID: https://orcid.org/0000-0002-7535-9339)
- April Park (ORCID: https://orcid.org/0009-0008-9487-0782)
- Yobouet Inès Kouakou
- Robert J. Lee (ORCID: https://orcid.org/0000-0001-5826-6686)
- Ryan M. Carey (ORCID: https://orcid.org/0000-0002-0186-2265)
- Nabil F. Darwich (ORCID: https://orcid.org/0000-0002-8324-9201)
- Joel C. Thompson
- Nithin D. Adappa (ORCID: https://orcid.org/0000-0002-0339-8769)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1002/alr.70084
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- National Institutes of Health