Apolipoprotein E genotypes are associated with diabetic peripheral neuropathy in Lebanese adults with type 2 diabetes: a case-control study
<i>APOE</i> genetic variants, especially <i>ϵ4</i>-containing genotypes, are associated with DPN susceptibility among Lebanese T2DM patients, independent of traditional risk factors including glycemic control. These population-specific findings require validation in prospective cohorts before clinical use but indicate potential value for <i>APOE</i> genotyping in DPN precision-risk models.
Authors
- Eddie Racoubian
- Akram Echtay
- Wassim Youssef Almawi (ORCID: https://orcid.org/0000-0003-1633-9757)
- Rita Nemr (ORCID: https://orcid.org/0000-0002-0859-198X)
- Sabrina Zidi (ORCID: https://orcid.org/0000-0002-5110-5211)
- Nisrine Beydoun
Institutions
- Rafik Hariri University Hospital (LB)
- University Medical Center Rizk Hospital (LB)
- American University of Beirut Medical Center (LB)
- Institut Pasteur de Tunis (TN)
- Tunis El Manar University (TN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fendo.2025.1738873
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00