Patient-Derived Monoclonal Myelin Oligodendrocyte Glycoprotein Autoantibodies Mediate Cytotoxicity
Taken together, the molecular characteristics and binding patterns of these patient-derived MOG-mAbs reveal a diverse repertoire of MOG-binding autoantibodies with pathogenic capacity in vitro. Consequently, these well-characterized patient autoantibodies offer a foundation for developing in vivo models of MOGAD, serve as tools to standardize diagnostic assays, and guide development of therapeutic strategies targeting either B cells or autoantibodies and their effector functions.
Authors
- Kristina Berve (ORCID: https://orcid.org/0009-0006-1680-7222)
- Laila Kulsvehagen (ORCID: https://orcid.org/0000-0001-5236-8323)
- Kevin C. O’Connor (ORCID: https://orcid.org/0000-0002-7056-419X)
- Beata Filipek (ORCID: https://orcid.org/0000-0003-4166-5650)
- Nora Sandrine Wetzel (ORCID: https://orcid.org/0000-0003-4991-4287)
- Anne-Catherine Lecourt (ORCID: https://orcid.org/0009-0003-4174-4049)
- Bert A. ‘t Hart (ORCID: https://orcid.org/0000-0002-0036-5267)
- Lucas Schirmer (ORCID: https://orcid.org/0000-0001-7142-4116)
- Gurumoorthy Krishnamoorthy (ORCID: https://orcid.org/0000-0002-7798-6707)
- Patrick Lipps (ORCID: https://orcid.org/0009-0002-5910-7622)
- Anne‐Katrin Pröbstel (ORCID: https://orcid.org/0000-0002-7748-1872)
- Soumya S. Yandamuri (ORCID: https://orcid.org/0000-0002-0325-6488)
- Laura Rieder
Institutions
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Heidelberg (DE)
- University Hospital of Basel (CH)
- Yale University (US)
- Amsterdam Neuroscience (NL)
- Bernstein Center for Computational Neuroscience Heidelberg-Mannheim (DE)
- Medical University of Lodz (PL)
- Department of Biomedicine Basel (CH)
- University Medical Centre Mannheim (DE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1212/nxi.0000000000200520
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47