Biological age threshold is associated with symptomatic knee osteoarthritis risk in chinese adults: Insights from machine learning analysis of a national cohort
BA is strongly and non-linearly associated with symptomatic KOA risk in Chinese adults, accelerating beyond a critical threshold. BA assessment may enhance KOA risk stratification and could inform future interventional studies. However, the cross-sectional design of this study precludes causal inferences. Longitudinal studies are required to establish temporal relationships and explore potential causal associations.
Authors
- Fanyu Fu (ORCID: https://orcid.org/0000-0002-1841-7379)
- Tingting Pang (ORCID: https://orcid.org/0000-0002-1144-1982)
- Jiwei Lian
- Dong Li (ORCID: https://orcid.org/0000-0001-5372-6006)
- Yufeng Wang (ORCID: https://orcid.org/0000-0001-6233-045X)
- Peng Liu (ORCID: https://orcid.org/0000-0003-4137-1740)
- Chang Liu (ORCID: https://orcid.org/0000-0001-6191-5173)
- Yunli Wang (ORCID: https://orcid.org/0000-0001-9337-5394)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Changchun University of Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1371/journal.pone.0335250
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00