Development and validation of a candidate reference measurement procedure for free triiodothyronine and free thyroxine in human serum using equilibrium dialysis isotope-dilution liquid chromatography-tandem mass spectrometry
This study developed a highly precise, accurate, specific, and sensitive ID-LC-MS/MS-based cRMP for the simultaneous measurement of FT3 and FT4 in human serum. This method provides a reliable tool for standardizing routine thyroid function tests.
Authors
- Min Zhan (ORCID: https://orcid.org/0000-0001-5699-4639)
- Zijia Ma (ORCID: https://orcid.org/0000-0001-5008-6250)
- Xianzhang Huang (ORCID: https://orcid.org/0000-0003-4320-9181)
- Wanlei Zhou (ORCID: https://orcid.org/0000-0002-1680-2521)
- Weiyan Zhou (ORCID: https://orcid.org/0000-0003-4174-6047)
- Jun Yan (ORCID: https://orcid.org/0000-0003-1552-8003)
- Liqiao Han
- Qiaoxuan Zhang (ORCID: https://orcid.org/0000-0002-3310-192X)
- Guoqiang Zheng (ORCID: https://orcid.org/0000-0002-4682-4190)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shenzhen Metro (China) (CN)
- National Center for Clinical Laboratories (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1515/cclm-2025-0874
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00