Cortical morphometric gradients reveal molecular and cognitive underpinnings of bipolar disorder
These findings reveal disrupted hierarchical cortical organization in BD and link macroscale morphometric alterations to specific neurotransmitter systems and transcriptional architectures. The MIND gradient emerges as a potential biomarker bridging structural disruptions with molecular and cognitive mechanisms in BD.
Authors
- Chunchao Xia (ORCID: https://orcid.org/0000-0003-4338-7199)
- Su Lui (ORCID: https://orcid.org/0000-0003-3541-1769)
- Xiaoqi Huang (ORCID: https://orcid.org/0000-0001-8686-5010)
- Jiajun Xu (ORCID: https://orcid.org/0000-0002-3260-383X)
- Qiyong Gong (ORCID: https://orcid.org/0000-0002-5912-4871)
- Fei Yue Li (ORCID: https://orcid.org/0000-0002-4737-5710)
- Huaiqiang Sun (ORCID: https://orcid.org/0000-0003-0687-6065)
- Rui Wang (ORCID: https://orcid.org/0009-0000-3553-1520)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725102705
- Citations
- 1
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Sichuan University
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University