Assessing the impact of temporal changes in transmission on Plasmodium falciparum strains in Asembo, western Kenya (1996–2017) using within-host metrics via 24-SNP barcodes
The within-host MOI, IBD-based strain-relatedness, and their mathematical relationship (slope) provide useful metrics for understanding the transmission dynamics in our study. Notably, this study presents the first simple slope-based method using 24-SNP barcodes to distinguish superinfection from co-transmission in a high transmission area, warranting further evaluation of the novel tool in other high transmission settings.
Authors
- Andrew Hill (ORCID: https://orcid.org/0000-0002-7418-6456)
- Aaron M. Samuels (ORCID: https://orcid.org/0000-0002-8355-8186)
- Feiko O. ter Kuile (ORCID: https://orcid.org/0000-0003-3663-5617)
- Simon Kariuki (ORCID: https://orcid.org/0000-0003-0554-1976)
- Ya Ping Shi (ORCID: https://orcid.org/0000-0003-0044-2610)
- Ýmir Vigfússon (ORCID: https://orcid.org/0000-0002-6812-4515)
- John E. Gimnig (ORCID: https://orcid.org/0000-0003-4218-447X)
- Kim A. Lindblade (ORCID: https://orcid.org/0000-0002-5593-0470)
- Meghna Desai (ORCID: https://orcid.org/0000-0002-6703-3355)
- Sheila B. Sergent
- Zhiyong Zhou (ORCID: https://orcid.org/0000-0002-6744-2757)
- Justin Lee (ORCID: https://orcid.org/0009-0009-6273-7183)
- Mili Sheth
- Laurence Slutsker
- Mary J. Hamel
- Kephas Otieno
- Gary Vestal
Institutions
- Emory University (US)
- Liverpool School of Tropical Medicine (GB)
- Kenya Medical Research Institute (KE)
- National Center for Emerging and Zoonotic Infectious Diseases (US)
- Computer Emergency Response Team (FR)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s12936-025-05700-3
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00