Classification of capillary damage in patients with type 2 diabetes mellitus: Clinical parameters obtained through capillaroscopy—A cross-sectional study

ObjectiveDiabetes mellitus (DM) significantly affects microcirculation, leading to microvascular abnormalities that can result in severe systemic complications. Capillaroscopy is a non-invasive and painless method for observing capillary microvasculature, allowing for the assessment of microcirculatory damage. While it is known primarily for its application in rheumatic diseases, recent studies have emphasized its importance in non-rheumatic conditions, such as DM. This growing relevance has led to the aim of developing a classification system for capillary damage in diabetic patients.MethodsCross-sectional study. Eighty randomly selected patients with type 2 diabetes mellitus (T2DM) were evaluated using capillaroscopy to assess capillary damage and establish a classification system.ResultsCapillary damage was observed in all participants (100%), with greater severity associated with longer diabetes duration. Patients were categorized based on the severity of their damage.ConclusionsThe classification system identified three degrees of capillary damage: an early grade, which can be subdivided into initial or established; an intermediate grade, which can also be initial or established (both treatable for potential reversibility); and an advanced grade, which appears to be irreversible. This classification aids in better understanding and managing microvascular damage in diabetic patients.

Authors

Institutions

Publication Details

Journal
Science Progress
Published
2025-10-01
DOI
https://doi.org/10.1177/00368504251384189
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Classification of capillary damage in patients with type 2 diabetes mellitus: Clinical parameters obtained through capillaroscopy—A cross-sectional study

Mariano Sotomayor de Zavaleta, Luis Fernando Flota-Cervera, F.J. González-García, Abdel Kerim Raffoul-Orozco et al.
Science Progress
Systemic Sclerosis and Related Diseases
article

Classification of capillary damage in patients with type 2 diabetes mellitus: Clinical parameters obtained through capillaroscopy—A cross-sectional study

Mariano Sotomayor de Zavaleta, Luis Fernando Flota-Cervera, F.J. González-García, Abdel Kerim Raffoul-Orozco, G Castañón, Daniel Zingg
article en

Abstract

ObjectiveDiabetes mellitus (DM) significantly affects microcirculation, leading to microvascular abnormalities that can result in severe systemic complications. Capillaroscopy is a non-invasive and painless method for observing capillary microvasculature, allowing for the assessment of microcirculatory damage. While it is known primarily for its application in rheumatic diseases, recent studies have emphasized its importance in non-rheumatic conditions, such as DM. This growing relevance has led to the aim of developing a classification system for capillary damage in diabetic patients.MethodsCross-sectional study. Eighty randomly selected patients with type 2 diabetes mellitus (T2DM) were evaluated using capillaroscopy to assess capillary damage and establish a classification system.ResultsCapillary damage was observed in all participants (100%), with greater severity associated with longer diabetes duration. Patients were categorized based on the severity of their damage.ConclusionsThe classification system identified three degrees of capillary damage: an early grade, which can be subdivided into initial or established; an intermediate grade, which can also be initial or established (both treatable for potential reversibility); and an advanced grade, which appears to be irreversible. This classification aids in better understanding and managing microvascular damage in diabetic patients.

Science ProgressVol. 108(4)
Instituto Tecnológico de Mérida (MX), Universidad de Guadalajara (MX), Vifor Pharma (Switzerland) (CH), Grünenthal Group (Germany) (DE), Instituto Vascular BH (BR), Vifor Pharma (United States) (US)
Openalex Percentile: Top 43%
Systemic Sclerosis and Related Diseases
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.