Enhanced bioproduction and processing of mandelic acid enantiomers: towards a sustainable platform for high-value pharmaceutical and polymer applications
This study establishes a robust proof of concept for a microbial platform enabling enantioselective MA biosynthesis from renewable carbon sources. Through the integration of metabolic engineering, downstream process development and application-driven validation, this platform lays the foundation for a scalable and industrially relevant bioproduction strategy. Aligned with the principles of green chemistry and the circular bioeconomy, this approach offers a sustainable and environmentally responsible route to high-value chiral chemicals.
Authors
- Aula A. Alwattar (ORCID: https://orcid.org/0000-0003-1958-4547)
- Viranga Tilakaratna (ORCID: https://orcid.org/0000-0003-4904-498X)
- Hanan L. Messiha (ORCID: https://orcid.org/0000-0002-7459-5057)
- Christopher Robinson (ORCID: https://orcid.org/0000-0001-6146-566X)
- Nigel Shaun Scrutton (ORCID: https://orcid.org/0000-0002-4182-3500)
- Alec Banner
- Rosalind Le Feuvre
- Mohamed Amer (ORCID: https://orcid.org/0000-0003-0424-1365)
Institutions
- University of Manchester (GB)
- Future Earth (CA)
Publication Details
- Journal
- Biotechnology for Biofuels and Bioproducts
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1186/s13068-025-02727-1
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 0.00