Immunomodulatory Role of Palladium(II) Complex with Ethyl Derivative of Thiosalicylic Acid Ligand

Many complexes have shown antitumor potential, including the bis(S-ethyl-2-thiosalicylate)palladium(II) complex. The aim of this study was to investigate potential immunomodulatory effects of this complex on acquired and innate immunity, in vitro. The effect was assessed based on the levels of cytokines tumor necrosis factor alpha (TNF-α), interleukin (IL) 1β, interferon gamma (IFN-γ), IL-17 and IL-10. Cytokine concentrations were measured by ELISA assay. Pd(II) complex led to a reduced secretion of most pro-inflammatory cytokines. The effects of the complex were more intense in non-activated cells. The same effect was shown in cells of acquired and innate immunity. These effects make the Pd(II) complex not only a potential antitumor agent, but also an anti-inflammatory agent.