MOG IgG3-Subclass Antibodies in MOG-Associated Disease
This case highlights the potential role of subclinical IgG1 deficiency in shaping the predominance or selective detection of MOG-IgG3 in MOGAD. While most MOG antibodies are predominantly of the IgG1 isotype, our review identified a few cases with isolated MOG-IgG3 antibodies. A possible contribution to pathogenesis cannot be excluded, and the patient's inability to produce a balanced IgG subclass profile could have favored a sustained IgG3 response. Larger studies are needed to clarify the clinical significance of MOG-IgG3 in MOGAD.
Authors
- Maria Pia Giannoccaro (ORCID: https://orcid.org/0000-0003-2208-376X)
- Francesca Conti (ORCID: https://orcid.org/0000-0002-3665-8926)
- Carla Corsini (ORCID: https://orcid.org/0009-0003-2812-0477)
- Marcello Lanari
- Duccio Maria Cordelli (ORCID: https://orcid.org/0000-0002-1367-6419)
- Mattia Moratti (ORCID: https://orcid.org/0000-0003-1133-9563)
- Luana Morelli (ORCID: https://orcid.org/0000-0002-7980-652X)
- Agnese Lopalco (ORCID: https://orcid.org/0009-0007-5391-3216)
- Fortuna Ricciardiello (ORCID: https://orcid.org/0000-0002-9848-5426)
- Rocco Liguori (ORCID: https://orcid.org/0000-0002-1815-1013)
- Francesco Toni (ORCID: https://orcid.org/0000-0002-1916-0077)
- Anna Fetta (ORCID: https://orcid.org/0000-0003-0175-6486)
Institutions
- University of Rome Tor Vergata (IT)
- Azienda USL di Bologna (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1212/nxi.0000000000200523
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute