Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases
This study provides the first detailed mapping of CD1a<sup>+</sup> and CD208<sup>+</sup> DCs across NAM, pCRC and paired LM, indicating that their prognostic impact is determined not only by absolute numbers but, more importantly, by compartmental distribution and the temporal pattern of metastasis.
Authors
- Ondřej Vyčítal (ORCID: https://orcid.org/0000-0001-7531-9751)
- Andriy Trailin (ORCID: https://orcid.org/0000-0001-8888-0759)
- Václav Liška (ORCID: https://orcid.org/0000-0002-5226-0280)
- Lenka Červenková (ORCID: https://orcid.org/0000-0001-7251-210X)
- Wenjing Ye (ORCID: https://orcid.org/0000-0003-0754-0643)
- Esraa Ali (ORCID: https://orcid.org/0000-0001-8962-2516)
- Sergii Pavlov (ORCID: https://orcid.org/0000-0002-0051-5560)
- Filip Ambrożkiewicz (ORCID: https://orcid.org/0000-0001-6850-780X)
- Ondřej Daum (ORCID: https://orcid.org/0000-0002-0930-7071)
- Kari Hemminki (ORCID: https://orcid.org/0000-0002-2769-3316)
Institutions
- Technical University of Liberec (CZ)
- German Cancer Research Center (DE)
- Charles University (CZ)
- Heidelberg University (DE)
- Krajská Nemocnice Liberec (CZ)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1007/s00262-025-04238-2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00