Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis
Among persons with tuberculous meningitis, no evidence of beneficial effect from high-dose rifampin was observed, and the potential for a harmful effect cannot be ruled out. (Funded by the U.K. Medical Research Council and others; ISRCTN Registry number, ISRCTN15668391.).
Authors
- Ananta Bangdiwala (ORCID: https://orcid.org/0000-0003-0062-9434)
- Vycke Yunivita (ORCID: https://orcid.org/0000-0001-7448-8684)
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- Nicole Engen (ORCID: https://orcid.org/0000-0003-1118-4194)
- Reinout van Crevel
- Timothy Mugabi (ORCID: https://orcid.org/0009-0006-8820-288X)
- David R. Boulware (ORCID: https://orcid.org/0000-0002-4715-0060)
- Enock Kagimu
- Ahmad Rizal Ganiem (ORCID: https://orcid.org/0000-0002-0290-2759)
- Sylvia Namanda
- Lindsey te Brake
- Nathan C. Bahr (ORCID: https://orcid.org/0000-0002-9431-8938)
- Lillian Tugume (ORCID: https://orcid.org/0000-0002-1293-1545)
- Noveline Sagita
- Biyue Dai (ORCID: https://orcid.org/0000-0002-4747-3687)
- Darma Imran (ORCID: https://orcid.org/0000-0002-4109-4192)
- Kogieleum Naidoo (ORCID: https://orcid.org/0000-0002-8874-6661)
- Jane Gakuru (ORCID: https://orcid.org/0000-0003-0150-4887)
- Maula Nuruddin Gaharu
- Mable Kabahubya
- Richard Lessells (ORCID: https://orcid.org/0000-0003-0926-710X)
- Abdu K Musubire (ORCID: https://orcid.org/0000-0003-2410-5344)
- Fiona V Cresswell (ORCID: https://orcid.org/0000-0002-5070-532X)
- Kartika Maharani (ORCID: https://orcid.org/0000-0003-2777-7015)
- Rob E. Aarnoutse (ORCID: https://orcid.org/0000-0001-8925-969X)
- Raph L Hamers (ORCID: https://orcid.org/0000-0002-5007-7896)
- Rovina Ruslami (ORCID: https://orcid.org/0000-0003-4995-5054)
- Suzaan Marais (ORCID: https://orcid.org/0000-0002-8050-9610)
- Sarah Kimuda (ORCID: https://orcid.org/0009-0002-1335-9787)
- Suzan Namombwe
- Riwanti Estiasari (ORCID: https://orcid.org/0000-0003-4792-0923)
- David B. Meya
- Mahomed Yunus Suleman Moosa
- Bongeka Hlabisa
- Media Yuni Kurniawati
Institutions
- Brighton and Sussex Medical School (GB)
- South African Medical Research Council (ZA)
- Uppsala University (SE)
- CHI Health Immanuel (US)
- University of Minnesota (US)
- Radboud University Nijmegen (NL)
- University of Cape Town (ZA)
- Queen Mary University of London (GB)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Care Institute of Medical Sciences (IN)
- Radboud University Medical Center (NL)
- University of Indonesia (ID)
- University of Oxford (GB)
- Dr. Hasan Sadikin General Hospital (ID)
- London School of Hygiene & Tropical Medicine (GB)
- Universitas Bhayangkara Jakarta Raya (ID)
- Radboud Institute for Molecular Life Sciences (NL)
- Infectious Diseases Institute (UG)
- Universitas Kristen Immanuel (ID)
- Bandung Islamic University (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Oxford University Clinical Research Unit Indonesia
- Makerere University (UG)
- Padjadjaran University (ID)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1056/nejmoa2502866
- Citations
- 7
- Primary Topic
- Infectious Diseases and Tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 14.04