Evaluation of systemic inflammation- and nutrition-based indices in the prediction of HPV persistence

When the researchers evaluated the subjects' systemic inflammatory and nutritional status, they found that HALP, PNI, PLR, and CRP did not provide effective predictive value for one-year HPV persistence. Conversely, NLR exhibited a promising capacity to function as a straightforward systemic inflammatory marker. The presence of HPV16 and HPV18 was found to be significantly associated with the persistence of the infection, thereby corroborating the established immune evasion mechanisms associated with these types. These findings underscore the necessity for prognostic markers that integrate both local mucosal immune responses and systemic inflammatory pathways to enhance risk stratification and management of HPV-related disease.