Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

The reversibility of synaptopathy, even at advanced stages, reinforces the importance of early detection of hyperexcitability and the development of effective therapeutic approaches.

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Publication Details

Journal
Epilepsia
Published
2025-12-17
DOI
https://doi.org/10.1111/epi.70024
Primary Topic
Glycogen Storage Diseases and Myoclonus
Type
article
Field-Weighted Citation Impact
0.00
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article

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Fabrizio Gardoni, Miriam Sciaccaluga, Paolo Prontera, Nerea Iglesias‐Cabeza et al.
Epilepsia
Glycogen Storage Diseases and Myoclonus
article

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Fabrizio Gardoni, Miriam Sciaccaluga, Paolo Prontera, Nerea Iglesias‐Cabeza, Alessandro Tozzi, Lucilla Parnetti, Marta Barzasi, Andrea Mancini, Cinzia Costa, Laura Bellingacci, Valentina Imperatore, Massimiliano Di Filippo, Luis Zafra‐Puerta, José M. Serratosa, Anna Aurora Taddei, Katiuscia Martinello, Jacopo Canonichesi, Marina P. Sánchez
article en

Abstract

The reversibility of synaptopathy, even at advanced stages, reinforces the importance of early detection of hyperexcitability and the development of effective therapeutic approaches.

EpilepsiaVol. 67(3)
Università degli studi di Cassino e del Lazio Meridionale (IT), University of Milan (IT), University of Perugia (IT), Fondazione Roma (IT), Istituto Neurologico Mediterraneo (IT), Azienda Ospedaliera di Perugia (IT), Hospital Universitario Fundación Jiménez Díaz (ES), Hospital Materno-Infantil (ES), Link Campus University (IT), Universidad Autónoma de Madrid (ES)
Openalex Percentile: Top 42%
Glycogen Storage Diseases and Myoclonus
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Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease — Fabrizio Gardoni, Miriam Sciaccaluga, et al. · Epilepsia (2025) | TGRS Research Map | TGRS