Cardiotoxicity in pediatric oncology: a systematic review and meta-analysis
Early detection of chemotherapy-induced cardiotoxicity in children remains unresolved. Multimodal assessment is most effective because no single test is sufficiently reliable. There are critical methodological gaps and heterogeneity that impede standardization in pediatric cardio-oncology. AI and microRNAs are promising but still unvalidated tools. The findings guide future clinical monitoring strategies and support standardized multimodal diagnostic algorithms.
Authors
- Tamás Kói (ORCID: https://orcid.org/0000-0003-0775-1088)
- Miklós Garami (ORCID: https://orcid.org/0000-0003-4298-2746)
- Andrea Párniczky (ORCID: https://orcid.org/0000-0003-3466-4780)
- Péter Hegyi (ORCID: https://orcid.org/0000-0003-0399-7259)
- Márk Hernádfői (ORCID: https://orcid.org/0009-0007-8653-2292)
- Kornél Lakatos
- Nóra Beke
- Xenia Jockers
Institutions
- Semmelweis University (HU)
- Budapest University of Technology and Economics (HU)
- Heim Pál Országos Gyermekgyógyászati Intézet (HU)
- University of Pecs (HU)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1038/s41390-025-04601-0
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
- National Research, Development and Innovation Office