Multi-omics analysis reveals diagnostic and therapeutic biomarkers for aging phenotypes in ulcerative colitis
Our findings underscore the pivotal roles of CXCL1, MMP9, and STAT1 in UC-associated cellular senescence. The analysis positions these molecules as promising macrophage-mediated diagnostic biomarkers and therapeutic targets. Collectively, this work provides novel insights into UC pathogenesis and lays a foundation for developing precision medicine strategies that target senescence pathways.
Authors
- Meili Liu (ORCID: https://orcid.org/0009-0009-5324-2779)
- Xinyi Zhang
- Yi Liu
- Cheng Li (ORCID: https://orcid.org/0000-0003-4366-6139)
- Jun Ge
- Zhenhua Wu (ORCID: https://orcid.org/0000-0003-4552-883X)
- Hong Jiang (ORCID: https://orcid.org/0000-0001-7692-5745)
- Lei Guo (ORCID: https://orcid.org/0009-0006-9773-4829)
- Wei Gong (ORCID: https://orcid.org/0009-0008-9817-5736)
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei University of Arts and Science (CN)
- Xiangyang Central Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1371/journal.pone.0338880
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00