Unusual spontaneous resolution of a nonfunctioning pituitary macroadenoma: A case report

This case highlights complete spontaneous regression of a symptomatic macroadenoma without apoplexy, possibly influenced by postpartum hormonal factors. Although surgical decompression remains the standard treatment for lesions causing chiasmal compression, this exceptional case demonstrates that, in rare situations where surgery is declined, repeat imaging and close monitoring may reveal unexpected regression. Careful multidisciplinary evaluation is essential to balance the risks of waiting against the potential for spontaneous resolution.

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Publication Details

Journal
Surgical Neurology International
Published
2025-11-21
DOI
https://doi.org/10.25259/sni_992_2025
Primary Topic
Pituitary Gland Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Unusual spontaneous resolution of a nonfunctioning pituitary macroadenoma: A case report

Mohammed El Faïz Chaoui, Marouane Hammoud, F. Lakhdar, Oualid Mohammed Hmamouche et al.
Surgical Neurology International
Pituitary Gland Disorders and Treatments
article

Unusual spontaneous resolution of a nonfunctioning pituitary macroadenoma: A case report

Mohammed El Faïz Chaoui, Marouane Hammoud, F. Lakhdar, Oualid Mohammed Hmamouche, Khalid Chakour, Mohammed Benzagmout, Mehdi Mdarhri
article en

Abstract

This case highlights complete spontaneous regression of a symptomatic macroadenoma without apoplexy, possibly influenced by postpartum hormonal factors. Although surgical decompression remains the standard treatment for lesions causing chiasmal compression, this exceptional case demonstrates that, in rare situations where surgery is declined, repeat imaging and close monitoring may reveal unexpected regression. Careful multidisciplinary evaluation is essential to balance the risks of waiting against the potential for spontaneous resolution.

Surgical Neurology InternationalVol. 16
Sidi Mohamed Ben Abdellah University (MA)
Openalex Percentile: Top 46%
Pituitary Gland Disorders and Treatments
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