Comprehensive radiologic-pathologic correlation in systemic sclerosis-associated interstitial lung disease: identification of an early-stage CT findings

SSc-ILD demonstrates predominantly diffuse fibrotic changes. Irregular reticulation with traction bronchiolectasis indicates UIP-like features, potentially identifying patients at risk for progression. FANO, observed most commonly in anterolateral upper lobes, frequently progresses to reticulation on longitudinal follow-up, suggesting potential value for early-stage detection. SSc-ILD demonstrated diffuse fibrotic changes as a characteristic feature, while irregular reticulation with traction bronchiolectasis indicated UIP-like fibrosis with severe architectural destruction. FANO, a newly described finding observed in 64% of cases, was predominantly in anterolateral upper lobes and corresponded to perivenular fibrosis and peribronchiolar metaplasia, representing potential early-stage changes.

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Publication Details

Journal
Japanese Journal of Radiology
Published
2025-12-18
DOI
https://doi.org/10.1007/s11604-025-01922-2
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
Field-Weighted Citation Impact
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article

Comprehensive radiologic-pathologic correlation in systemic sclerosis-associated interstitial lung disease: identification of an early-stage CT findings

Hiromitsu Sumikawa, Hiroya Ojiri, Kensuke Kataoka, Tomonori Tanaka et al.
Japanese Journal of Radiology
Systemic Sclerosis and Related Diseases
article

Comprehensive radiologic-pathologic correlation in systemic sclerosis-associated interstitial lung disease: identification of an early-stage CT findings

Hiromitsu Sumikawa, Hiroya Ojiri, Kensuke Kataoka, Tomonori Tanaka, Mikiko Hashisako, Takeshi Johkoh, Midori Ueno, Mai Matsumura, Yuki Ko, Ryoko Egashira, Junya Fukuoka, Yasuhiko Yamano, Tomoki Kimura, Taiki Fukuda, Yasuhiro KONDOH, Hiroto Hatabu, Reoto Takei, Junya Tominaga, Daisuke Yamada, Kaori Ishida, Y. Nakamura
article en

Abstract

SSc-ILD demonstrates predominantly diffuse fibrotic changes. Irregular reticulation with traction bronchiolectasis indicates UIP-like features, potentially identifying patients at risk for progression. FANO, observed most commonly in anterolateral upper lobes, frequently progresses to reticulation on longitudinal follow-up, suggesting potential value for early-stage detection. SSc-ILD demonstrated diffuse fibrotic changes as a characteristic feature, while irregular reticulation with traction bronchiolectasis indicated UIP-like fibrosis with severe architectural destruction. FANO, a newly described finding observed in 64% of cases, was predominantly in anterolateral upper lobes and corresponded to perivenular fibrosis and peribronchiolar metaplasia, representing potential early-stage changes.

Japanese Journal of Radiology
Jikei University School of Medicine (JP), Kansai Medical University (JP), Brigham and Women's Hospital (US), Kyushu University (JP), Harvard University (US), Aichi Medical University (JP), Saga University (JP), Kobe University Hospital (JP), Tohoku University Hospital (JP), Kyushu University Hospital (JP), Kansai Rosai Hospital (JP), Saitama Medical University Hospital (JP), Tosei General Hospital (JP), NHO Kinki Chuo Chest Medical Center (JP), Nagasaki University (JP), University College London (GB), Saitama Medical University (JP), The University of Osaka (JP)
Openalex Percentile: Top 43%
Systemic Sclerosis and Related Diseases
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