Benefits, Harms, and Burden of Colorectal Cancer Screening Among Childhood Cancer Survivors Previously Treated With Abdominopelvic Radiation
Early initiation of screening with colonoscopy or stool-based tests may substantially reduce CRC incidence and early mortality among survivors treated with abdominopelvic RT, with reasonable burden-to-benefit trade-offs, and be considered cost-effective. These findings can facilitate clinician-survivor discussions on CRC screening and inform guideline refinements.
Authors
- Claudia L. Seguin (ORCID: https://orcid.org/0000-0002-1076-5563)
- Lisa Diller (ORCID: https://orcid.org/0000-0002-4073-5509)
- Kayla L. Stratton (ORCID: https://orcid.org/0000-0002-5201-4565)
- Jennifer M. Yeh (ORCID: https://orcid.org/0000-0002-2724-7404)
- Paul Craig Nathan (ORCID: https://orcid.org/0000-0003-0334-0871)
- Amy B. Knudsen (ORCID: https://orcid.org/0000-0003-1872-996X)
- Gregory T. Armstrong (ORCID: https://orcid.org/0000-0001-8722-4207)
- Wendy M. Leisenring (ORCID: https://orcid.org/0000-0001-7405-0906)
- Kevin Charles Oeffinger (ORCID: https://orcid.org/0000-0003-0806-7894)
- Joseph P. Neglia (ORCID: https://orcid.org/0000-0002-5525-0598)
- Tara Olive Henderson (ORCID: https://orcid.org/0000-0001-9394-6206)
- Melissa M. Hudson (ORCID: https://orcid.org/0000-0001-6984-2407)
Institutions
- Boston Children's Hospital (US)
- St. Jude Children's Research Hospital (US)
- Harvard University (US)
- Duke University (US)
- Hospital for Sick Children (CA)
- Massachusetts General Hospital (US)
- Northwestern Memorial Hospital (US)
- Fred Hutch Cancer Center (US)
- Center for Assessment (US)
- Lurie Children's Hospital (US)
- Duke Medical Center (US)
- University of Minnesota Medical Center (US)
- Boston Children's Museum (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1200/jco-25-00661
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00