Effectiveness of <i>Fagopyrum esculentum</i> in atopic dermatitis: A single-arm clinical trial

Objectives: The main objective of this study was to evaluate the usefulness of Fagopyrum esculentum in treating AD. Material and Methods: This was an open-label, prospective, single-arm clinical trial conducted on 35 participants with AD treated at the outpatient department of a Government Homoeopathic Medical College and Hospital. Being a single-arm study, all participants received F. esculentum and were assessed over a 3-month treatment period. The AD severity index (ADSI) and the children’s dermatology life quality index (CDLQI) were used as the primary and secondary outcome measures, respectively, and were assessed at baseline and after 3 months. The intention-to-treat (ITT) approach was used for statistical analysis. Data distribution was examined. A non-parametric Wilcoxon signed-rank test and a post hoc parametric paired t -test were used accordingly. P &lt; 0.05 was considered statistically significant. Results: Three patients dropped out, and 32 completed the trial. ITT sample ( n = 35) was analysed at the end. There were statistically significant reductions in both ADSI score (4.834 ± 2.269–0.840 ± 1.165; mean reduction 3.994, 95% confidence intervals [CI]: 3.27–4.71, P &lt; 0.001) and CDLQI (12.228 ± 3.993–2.771 ± 2.015; mean reduction 9.457, 95% CI: 8.20, 10.71, P &lt; 0.001) over 3 months of treatment. Conclusion: The study findings suggest that F. esculentum is beneficial in the treatment of AD as well as improving the quality of life. More randomised controlled trials on this clinical condition are further warranted.