Two previously undescribed megastigmane glycosides from the leaves of <i>Sapium discolour</i> and their NO inhibitory activity
Using a combination of chromatographic techniques, two previously undescribed megastigmane glycosides, namely sapidisides A and B (<b>1</b> and <b>2</b>), along with 15 known metabolites (<b>3</b>-<b>17</b>), were identified from <i>S. discolour</i> leaves. Their structures were established by HRESIMS, NMR spectroscopic analyses, and experimental ECD spectra. Among them, metabolites <b>1</b>, <b>2</b>, <b>5</b>, <b>9</b>, and <b>10</b> exhibited suppression effects on NO production in LPS-induced RAW264.7 cells (IC<sub>50</sub>: 24.4-48.7 <i>μ</i>M), compared with the positive control dexamethasone (IC<sub>50</sub>: 13.12 <i>μ</i>M).
Authors
- Bùi Hữu Tài (ORCID: https://orcid.org/0000-0002-2034-3786)
- Ninh Khac Thanh Tung
- Bùi Văn Thanh
- Trần Mỹ Linh (ORCID: https://orcid.org/0000-0001-8246-2206)
- Ninh Khắc Bản
- Nguyễn Phương Thảo (ORCID: https://orcid.org/0000-0002-8793-2593)
- Phan Kiem
- Phan Thị Thanh Hương
Institutions
- Centre for Research and Development (ZW)
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1080/14786419.2025.2600510
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00