Electroencephalography‐based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high‐risk for progression to dementia
Electroencephalography (EEG) markers differentiate resilience and progression in mild cognitive impairment (MCI) individuals with high-risk biomarker profiles.Converters (cMCI) show increased delta power, reduced alpha activity, and higher delta/alpha ratios, indicating cortical dysfunction.Resilient MCI (sMCI) maintain healthy delta profiles, enhanced frontal alpha power, and stronger anterior connectivity.Graph-theoretical analysis reveals higher small-world (SW) index in resilient MCI, suggesting efficient and flexible network organization.EEG is a non-invasive, accessible tool to capture both risk and resilience factors, with potential for early diagnosis and personalized interventions.
Authors
- Fabrizio Tagliavini (ORCID: https://orcid.org/0000-0003-1039-7315)
- Stefano Francesco Cappa (ORCID: https://orcid.org/0000-0003-1003-3925)
- Flavia Lombardo (ORCID: https://orcid.org/0000-0001-6183-0735)
- Nicola Vanacore (ORCID: https://orcid.org/0000-0003-2817-3758)
- Patrizia Spadin
- Daniela Perani (ORCID: https://orcid.org/0000-0002-3421-204X)
- Naike Caraglia
- Chiara Pappalettera (ORCID: https://orcid.org/0000-0002-0020-6274)
- Lorenzo Nucci (ORCID: https://orcid.org/0000-0001-9463-7501)
- Camillo Marra (ORCID: https://orcid.org/0000-0003-3994-4044)
- Alessia Cacciotti (ORCID: https://orcid.org/0000-0001-6484-5334)
- Davide Quaranta (ORCID: https://orcid.org/0000-0003-2905-6625)
- Alberto Redolfi (ORCID: https://orcid.org/0000-0002-4145-9059)
- Fabrizio Vecchio (ORCID: https://orcid.org/0000-0002-6004-9522)
- Francesco Iodice (ORCID: https://orcid.org/0000-0003-4817-8089)
- Maria Cotelli (ORCID: https://orcid.org/0000-0003-3208-3798)
- Paolo Maria Rossini
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Vita-Salute San Raffaele University (IT)
- Università degli Studi eCampus (IT)
- Istituto Superiore di Sanità (IT)
- Istituto Universitario di Studi Superiori di Pavia (IT)
- Agostino Gemelli University Polyclinic (IT)
- National Centre for Disease Prevention and Control (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Associazione Italiana per l'Agricoltura Biologica (IT)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/trc2.70194
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Ministero della Salute
- Agenzia Italiana del Farmaco, Ministero della Salute