The Effects of Ficus carica Latex on SH-SY5Y Neuroblastoma Cells and L929 Fibroblast Cells

Aim: This study aims to evaluate the anti-cancer effect of latex obtained from Ficus carica on SH-SY5Y neuroblastoma cells and its wound healing potential on L929 fibroblast cells. Materials and Methods:The effects of Ficus carica latex were investigated in vitro.A scratch wound model was created on L929 cells and treated with 1-1000 g/mL of Ficus carica latex.Microscopic images were taken at 0 and 48 hours to measure the wound areas.In SH-SY5Y cells, cytotoxicity was assessed using the MTT assay, and the IC 50 value was determined.Results: Ficus carica latex promoted significant wound healing in L929 cells, particularly at concentrations of 5 g/mL and above, associated with increased proliferation.In SH-SY5Y cells, no cytotoxic effects were observed at 1-50 g/mL, whereas cytotoxicity was evident at 100 g/mL and 1000 g/mL. Conclusion:Ficus carica latex significantly promoted wound healing even at low doses, mainly by enhancing cell proliferation.On the other hand, it exhibited marked cytotoxic effects on neuroblastoma cells at high doses.These findings suggest that Ficus carica latex could be a potential therapeutic agent for wound healing but should be used in a dose-controlled manner for cancer cells like neuroblastoma.