Long-term DNA methylation changes induced by age and elevated CO2 in skeletal muscle
Hypercapnia causes durable muscle wasting that persists even after regaining ambient air environment, which is associated with a perturbed methylome landscape. High CO<sub>2</sub>-induced DNA methylation changes do not overlap with age-induced differentially methylation positions and are independent of substrate imbalances and autophagy regulation.
Authors
- Andy Madrid (ORCID: https://orcid.org/0000-0001-8612-5995)
- Reid S. Alisch (ORCID: https://orcid.org/0000-0003-0637-4137)
- Joseph Balnis (ORCID: https://orcid.org/0000-0003-0894-2839)
- Emily Jackson (ORCID: https://orcid.org/0000-0003-1096-0331)
- Harold A. Singer (ORCID: https://orcid.org/0000-0001-8554-3239)
- Ariel Jaitovich (ORCID: https://orcid.org/0000-0003-4714-2260)
- Lisa A. Drake (ORCID: https://orcid.org/0000-0002-3217-1715)
- Catherine E. Vincent
Institutions
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- Neurological Surgery (US)
- Albany Medical Center Hospital (US)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s13395-025-00406-1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00