Glioblastoma zebrafish Avatars guide therapeutic decisions in a patient with gliosarcoma: a case report
The rapid establishment of zAvatars from glioblastoma tumor samples allows for the testing of drug combinations and the tailoring of treatment in a personalized and timely manner. A future pipeline of tumor sequencing together with zAvatars testing, since the first surgery, may help manage patients more effectively, potentially improving their Progression free survival (PFS) and overall survival (OS).
Authors
- Joana Ruivo (ORCID: https://orcid.org/0000-0002-4857-9643)
- Márcia Fontes (ORCID: https://orcid.org/0009-0006-5397-2550)
- Manuela Mafra (ORCID: https://orcid.org/0000-0002-0623-4102)
- José Bravo Marques (ORCID: https://orcid.org/0000-0001-9848-5832)
- Jorge Lima (ORCID: https://orcid.org/0000-0001-7780-0901)
- Rita Fior (ORCID: https://orcid.org/0000-0001-5550-2428)
- Carlos Albuquerque (ORCID: https://orcid.org/0000-0002-7674-6760)
- Daniela Garcez (ORCID: https://orcid.org/0000-0002-0684-7347)
- Catarina Viegas
- Miguel da Cruz-Ribeiro
Institutions
- Champalimaud Foundation (PT)
- Universidade do Porto (PT)
- Instituto Superior Autónomo de Estudos Politécnicos (PT)
- Companhia União Fabril (PT)
- CUF Porto Hospital (PT)
- Hospital do Desterro (PT)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1038/s43856-025-01314-7
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Fundação Champalimaud
- Fundação para a Ciência e a Tecnologia