Hydroxyurea utilization among individuals with sickle cell disease in Tennessee: a pooled analysis of claims data
In our pooled statewide analysis, hydroxyurea MPR was low. Higher hydroxyurea use was associated with decreased acute healthcare utilization and lower mortality. Interventions to support patient adherence and provider prescribing are required to improve health outcomes among individuals with SCD.
Authors
- Jerlym S. Porter (ORCID: https://orcid.org/0000-0003-0173-6522)
- Wendy Stevens
- Jane S. Hankins (ORCID: https://orcid.org/0000-0003-4439-7321)
- Allison Plaxco
- Judy Dudley
- Andrew David Wiese (ORCID: https://orcid.org/0000-0002-0699-4224)
- Lisa M. Klesges (ORCID: https://orcid.org/0000-0001-6237-4743)
- Ayesha Mukhopadhyay (ORCID: https://orcid.org/0009-0005-3608-0385)
- William O. Cooper (ORCID: https://orcid.org/0000-0001-8527-4569)
- Chinonyelum Nwosu (ORCID: https://orcid.org/0000-0003-1079-7829)
- Meredith Ray (ORCID: https://orcid.org/0000-0001-5312-3774)
- Sherif M. Badawy (ORCID: https://orcid.org/0000-0002-4739-265X)
- Joacy G. Mathias (ORCID: https://orcid.org/0000-0002-3378-9568)
- James G. Gurney
- Matthew Smeltzer
Institutions
- University of North Carolina at Chapel Hill (US)
- Lurie Children's Hospital (US)
- St. Jude Children's Research Hospital (US)
- Washington University in St. Louis (US)
- Vanderbilt University Medical Center (US)
- University of Memphis (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fphar.2025.1693126
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention
- National Heart, Lung, and Blood Institute