Fatty acid binding protein 4 induces osteogenesis and angiogenesis as pathogenesis of metabolic osteoarthritis
This study suggests that FABP4 induced subchondral bone osteogenesis and angiogenesis. The PI3K-Akt signaling pathway plays a critical role in both processes. Inhibition of FABP4 may serve as a potential therapeutic approach for metabolic OA.
Authors
- Ying Huang (ORCID: https://orcid.org/0000-0001-9951-6290)
- Yinjun Mao (ORCID: https://orcid.org/0000-0002-4541-9222)
- Wenming Zhang (ORCID: https://orcid.org/0000-0003-1567-7279)
- Hongyan Li (ORCID: https://orcid.org/0000-0001-9300-610X)
- Yunzhi Lin (ORCID: https://orcid.org/0000-0003-2584-945X)
- Mengsi Cai (ORCID: https://orcid.org/0009-0008-8711-7135)
- Zida Huang (ORCID: https://orcid.org/0000-0002-5204-2005)
- Yiming Lin (ORCID: https://orcid.org/0000-0002-4776-4441)
- Yang Chen (ORCID: https://orcid.org/0000-0001-7168-7098)
- Xinyu Fang (ORCID: https://orcid.org/0000-0001-6337-8009)
- Chaofan Zhang (ORCID: https://orcid.org/0000-0001-7397-2298)
- Yishan Xin (ORCID: https://orcid.org/0009-0003-5013-9916)
- X Zhang (ORCID: https://orcid.org/0000-0002-3991-2379)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s10020-025-01330-2
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00