The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years
The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 21 twin studies from 5 countries (Australia, Denmark, Finland, Sweden, and United States) established to explore the nature of gene-environment interplay in cognitive, physical, and emotional health across the adult lifespan. The combined data from over 145,000 participants (aged 18 to 108 years at intake) has supported multiple research projects over the three phases of development since its inception in 2010. Phases 1 and 2 focused on launching and growing the consortium and supported important developments in data harmonization, analyses of data pooled across multiple studies, incorporation of linkages to national registries and conscription data, and integration of molecular genetic and classical twin designs. IGEMS Phase 3 focuses on developing appropriate infrastructure to maximize utilization of this large twin consortium for aging research.
Authors
- Jenae M. Neiderhiser (ORCID: https://orcid.org/0000-0003-4474-5330)
- Nicholas G. Martin (ORCID: https://orcid.org/0000-0003-4069-8020)
- Michelle K. Lupton (ORCID: https://orcid.org/0000-0002-7274-7299)
- Eero Vuoksimaa (ORCID: https://orcid.org/0000-0002-6534-3667)
- Kaare Christensen (ORCID: https://orcid.org/0000-0002-5429-5292)
- Elina Sillanpää (ORCID: https://orcid.org/0000-0001-6375-959X)
- Deborah Finkel (ORCID: https://orcid.org/0000-0003-2346-2470)
- Oliver Hayden (ORCID: https://orcid.org/0000-0002-2678-8663)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Chandra A. Reynolds (ORCID: https://orcid.org/0000-0001-6502-7173)
- Ellen E. Walters
- Marianne Nygaard (ORCID: https://orcid.org/0000-0003-0703-2665)
- Miriam Anna Mosing (ORCID: https://orcid.org/0000-0003-2049-125X)
- Matt McGue (ORCID: https://orcid.org/0000-0002-5580-1433)
- Margaret Gatz (ORCID: https://orcid.org/0000-0002-1071-9970)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Brian Karl Finch (ORCID: https://orcid.org/0000-0003-1730-1574)
- Ida Karlsson (ORCID: https://orcid.org/0000-0003-3605-7829)
- William S. Kremen
- Keith E. Whitfield
- Nancy L. Pedersen
- Robert F. Krueger
- Elizabeth Prom-Worley
Institutions
- University of California, Riverside (US)
- University of Southern California (US)
- University of Minnesota (US)
- Pennsylvania State University (US)
- University of Helsinki (FI)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- University of Southern Denmark (DK)
- Virginia Commonwealth University (US)
- University of Colorado Boulder (US)
- QIMR Berghofer Medical Research Institute (AU)
- Johns Hopkins Medicine (US)
- University of Minnesota System (US)
- California Southern University (US)
- Odense University Hospital (DK)
- University of Colorado System (US)
- Karolinska Institutet (SE)
- UNSW Sydney (AU)
- University of California San Diego (US)
- Max Planck Institute for Empirical Aesthetics (DE)
- Institute for Molecular Medicine Finland (FI)
- Jönköping University (SE)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Twin Research and Human Genetics
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1017/thg.2025.10036
- Citations
- 1
- Primary Topic
- Cognitive Abilities and Testing
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- U.S. Department of Veterans Affairs
- John D. and Catherine T. MacArthur Foundation
- W. M. Keck Foundation
- Vårdalstiftelsen
- Virginia Commonwealth University
- Center of Excellence for Stress and Mental Health
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Vetenskapsrådet
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Institute on Aging
- FP7 Health