Efficacies of Sequenced Monotherapies of <i>Mycobacterium avium</i> Lung Infection in Mouse
These findings provide the first evidence that sequential monotherapy can deliver efficacy comparable to multidrug therapy for M. avium disease without promoting resistance. This proof-of-concept supports further investigation of sequencing strategies as a potentially more tolerable alternative to current triple-agent regimens.
Authors
- Gyanu Lamichhane (ORCID: https://orcid.org/0000-0002-2214-0114)
- Binayak Rimal (ORCID: https://orcid.org/0000-0003-3457-4523)
- Chandra M. Panthi
- Ruth A. Howe
- Jay Khandelwal (ORCID: https://orcid.org/0009-0003-5593-6009)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1093/infdis/jiaf640
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fisher Center for Alzheimer's Research Foundation
- Johns Hopkins University
- National Institutes of Health