Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia
ESC-derived <i>Phd2</i> <sup>+/-</sup> MØs display robust proresolution and proangiogenic activities, promoting functional recovery in ischemic muscle. These findings support their potential as a novel cell-based therapy for ischemia-related conditions and highlight the opportunity to develop patient-specific <i>Phd2</i> <sup>+/-</sup> MØs from induced pluripotent stem cells (iPSCs) for future clinical application.
Authors
- Gustavo J.S. Pereira (ORCID: https://orcid.org/0000-0002-6765-1276)
- Sayone Andrade de Moura
- Gabriel Cicolin Guarache
- Leonardo Martin
- Ivan Hong Jun Koh (ORCID: https://orcid.org/0000-0001-5076-789X)
- Bianca Bonetto Moreno Garcia
- A Fidanza (ORCID: https://orcid.org/0000-0002-1266-6454)
- Aléx Martins Nasare
- Patrícia Terra Alves (ORCID: https://orcid.org/0000-0002-6285-8163)
- André van Helvoort Lengert (ORCID: https://orcid.org/0000-0002-3632-343X)
- Lesley M. Forrester (ORCID: https://orcid.org/0000-0002-9717-8299)
- Cristiane Damas Gil (ORCID: https://orcid.org/0000-0001-6979-4126)
- Sang Won Han (ORCID: https://orcid.org/0000-0002-4953-7680)
- Helen Taylor (ORCID: https://orcid.org/0000-0003-2376-7258)
Institutions
- University of Antwerp (BE)
- MRC Centre for Regenerative Medicine (GB)
- Province of Antwerp (BE)
- Universidade Federal de São Paulo (BR)
- University of Edinburgh (GB)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fphar.2025.1698623
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council