Cardiometabolic Candidate Endotypes in Psoriatic Disease: Integration of Clinical, Metabolic, and Immunogenetic Data Across Psoriasis and Psoriatic Arthritis
Incorporating HLA-Cw6 into clustering identified reproducible cardiometabolic phenotypes with distinct genetic signatures. The inverse HLA-Cw6 risk patterns in PsO and PsA suggest disease-specific patterns that may have differing cardiometabolic implications, which should be tested in longitudinal studies.
Authors
- Marta Loredo (ORCID: https://orcid.org/0009-0005-8084-2068)
- Estefanía Pardo
- Sara Alonso (ORCID: https://orcid.org/0000-0003-0560-6362)
- Mercedes Alperí (ORCID: https://orcid.org/0000-0002-8727-0876)
- Stefanie Burger (ORCID: https://orcid.org/0009-0003-4827-8829)
- Rubén Queiró (ORCID: https://orcid.org/0000-0002-8418-7145)
- Ignacio Braña (ORCID: https://orcid.org/0009-0008-0158-0496)
- Paula Alvarez (ORCID: https://orcid.org/0009-0000-0795-4307)
- Norma Callejas
Institutions
- Universidad de Oviedo (ES)
- Hospital Universitario Central de Asturias (ES)
Publication Details
- Journal
- Life
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3390/life16010002
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00